Abstract: This paper puts forward the definition of intelligent ventilation system, analyzes the key technology of intelligent ventilation in coal mines, and studies the accurate acquisition algorithm based on the parameters of mine detection and monitoring system. An adaptive optimization method of mine ventilation network based on minimum regulated power consumption is established to realize the on-demand air distribution in coal mines. The simulation and real-time calculation system of mine ventilation is established. The intelligent optimization algorithm is applied in the optimization of mine ventilation system and the decision measures of the intelligent adjustment of wind resistance fan. Taking the No.8272 working face of Yangdong Coal Mine of Jizhong Energy Fengfeng Group as the experimental object, the reliability of the key technology of intelligent ventilation proposed in this paper is verified.