Abstract: In order to control the water inrush of Ⅲ638 working face floor verification borehole in Zhuzhuang Coal Mine, we first analyzed the reasons of the water inrush, and confirmed that the inrush water source was L₃ limestone water, and the water channel was the floor karst development zone that had not been thoroughly controlled and JF₁, JF₂, JF₃ faults. We proposed the idea of integrated treatment of water source and channel by using ground regional prevention and control. The treatment area is divided into water inrush risk area, fault influence area and deep weak area. Depend on “border locking + regional prevention and control”, different borehole layout schemes are proposed for different areas. Gradient pressurization grouting technology is used to reconstruct and reinforce the L₃ limestone aquifer and faults. The drilled holes all meet the design requirements. After the treatment, the effect was verified by index evaluation, cross inspection and drilling. There is no floor water inrush after the treatment. The results show that the water source and channel integrated treatment technology based on ground regional prevention and control has advantages in blocking the floor water inrush.