Abstract: Influenced by the coupling effect of “slope stress field” and “roadway group stress field”，the influencing factors of slope stability in end-slope mining field are more complex and the difficulty of slope stability control is significantly increased. In order to find out the main influencing factors and action rules of slope stability in end-slope mining field, taking the end slope coal mining of an open-pit mine in Ordos area as the background, numerical analysis model was constructed, the movement and deformation characteristics of slope rock and soil mass under different slope angles, different width-height ratios of coal pillars and different mining depths are simulated and studied, and the differences of the influence of each key factor on slope stability are compared and analyzed. The results show that the overall slope angle, the width-height ratio of coal pillar and the depth of mining roadway group have obvious influence on the movement and deformation of rock and soil mass of slope in end-slope mining field. The slope stability decreases with the increase of the overall slope angle, increases with the increase of width-height ratio of coal pillar, and taking the orthographic projection position of the slope top line in the coal seam as the boundary, when the end of roadway does not exceed this boundary, the increase of roadway depth is not conducive to slope stability, when the end of roadway exceeds this boundary, the increase of roadway depth will be beneficial to slope stability.