Abstract: In order to analyze the various influencing factors and their configuration paths of human-caused accidents in coal mines, through adopting the clear set qualitative comparative analysis method（ｃｓＱＣＡ） and taking 25 typical human-caused accident cases as the research object, this paper selects seven conditional variables: human factors, safety supervision, organization and management, equipment and facilities, complex environment, safety norms and safety culture to discuss the group configuration and multiple paths of human-caused accidents in coal mines. The results show that there are seven configuration paths in the formation of human-caused accidents in coal mines, and the associative effect is shown among the conditional variables in the seven configuration paths. In addition, different conditional variables have different influence on human-caused accidents in coal mines. Among them, safety norms, complex environment, organization management and safety supervision impose important effect on the occurrence of human accidents, and the organization management is particularly critical. Finally, this paper proposes the measures and suggestions to prevent human-caused accidents in coal mines based on the research results.