Abstract: Mine ventilation system is the “lung” of the mine, maintaining the underground working environment, and ensuring the health and life safety of underground personnel. With the continuous development of intelligent technology in recent years, China has put forward the safety production guiding ideology of “mechanized replacement, intelligent reduction”, which can improve the safety production level of coal mines by reducing the number of front-line workers in coal production. Through investigation, it is concluded that the demand of the mine ventilation intelligent control system. In order to realize the system requirements, we design a set of modular mine ventilation intelligent control system, the intelligent module contains the main ventilator control system, intelligent control system of auxiliary fan, air door window intelligent control system and precise wind system, etc. The mine ventilation intelligent control system designed has been applied in Dashuitou Coal Mine in Gansu Province, which realizes intelligent control of mine ventilation system and special personnel inspection operation, improves the safety and reliability of mine ventilation and the precision of air volume regulation, reduces ventilation energy consumption and reduces the workload of ventilation management personnel.