Abstract: This paper discusses the construction method of ventilation and prevention system based on the application practice of Zhuanlongwan Coal Mine. A precise perception technology for key parameters of ventilation network is proposed. Through the optimal arrangement of sensors and the use of the least monitoring points, the correlation parameter analysis of the whole mine ventilation resistance route is achieved; the remote software modules of the main ventilator, local ventilator, and ventilation facilities are developed by extracting the ventilation and prevention information of the safety monitoring system, and the modules such as beam pipe monitoring, dust monitoring, grouting monitoring, and personnel positioning system are integrated; the intelligent analysis technology for the state of the ventilation and prevention system is proposed, and the three-dimensional simulation model of the mine ventilation network is established, which achieves the real-time calculation of the ventilation network, the visual display and trend analysis of the ventilation and prevention parameters, and the diagnosis and early warning of ventilation anomalies. By organically integrating ventilation, gas, fire, dust and other ventilation and prevention safety information, a hierarchical management and control mode of mine ventilation and prevention system based on multi heterogeneous information integration is proposed, a mine intelligent ventilation and prevention platform is developed, and mine emergency management and control platform is invented. Through field practice, the relevant parameter judgment and control model are verified, which provides application experience for the construction of mine intelligent ventilation and prevention system.