Abstract: Pipeline transportation of liquid CO₂ can not only prevent coal mine fires, but also effectively store greenhouse gase CO₂ in underground, which is in line with the current global economic development model. Due to the temperature difference of the mine environment and the inclination of the roadway, heat exchange and large pressure drop will inevitably occur in the pipeline. In order to avoid the phase change of liquid CO₂ during transportation, it is necessary to consider factors such as ambient temperature, wind speed, insulation cotton, pipeline inclination, and terrain elevation to ensure safe, cost-effective transportation. Based on the commercial simulation software ASPEN HYSYS V8.4, this paper simulates the process of liquid CO₂ transportation. The results show that the inclination of the pipeline has a great influence on the CO2 transportation process among environmental factors and is conducive to liquid CO2 transportation.