Abstract: In order to solve the open-pit slope stability problems under the disturbance of underground mining, combining theoretical research and on-site, the slope deformation mechanism under the conditions of combining open-pit with underground mining is discussed. Combined the actual production of North part of Anjialing Open-pit and No.2 coal mine, under the premise of monitoring, it is controlled by optimizing the time-space relationship of open-pit and underground, which ensures the safe and efficient production in Anjialing Coal Mine under the open and underground mining conditions.