Abstract: In order to prevent the large deformation of the surrounding rock of the mine and improve the stability of the unstable rock mass, the parameters of the cement anchoring agent material were optimized based on the orthogonal design method and the rock mass mechanical test; the amount of fly ash, water glass, the amount of ettringite, the amount of naphthalene sulfonate, the water-cement ratio, and the sand-cement ratio are the raw materials. Three physical and mechanical properties of uniaxial compressive strength, gripping force, and adhesive force were obtained through testing. The results were analyzed by range and variance to obtain the order and degree of influence. The results show that the greatest effect on the gripping force is the amount of fly ash, and the water-cement ratio, sand-cement ratio, and water glass content also have significant effects on the gripping force; the influence of the amount of bauxite and water-cement ratio on the adhesion force is second. Multivariate linear regression analysis was performed using the data obtained from the experiments, and the empirical equations for the mechanical indexes of the specimens and the ratio of the anchoring agent materials were obtained. It can be used to improve the safety of the surrounding rock anchoring system.