Abstract: In order to prevent spontaneous combustion in goaf caused by long withdrawal period of spontaneous combustion working face in rock burst mine, by analyzing the characteristics of fire prevention and extinguishing during the withdrawal period of working face in thick coal seam prone to spontaneous combustion under rock burst condition, an accurate control technology of air leakage in multi-layer goaf is proposed, which is based on the measures of ground fissure plugging, air leakage plugging in pressure regulating chamber, O-ring plugging and pressure regulating of ventilation system. An accurate control technology of oxidation zone width in goaf by means of full-section curtain nitrogen injection technology in goaf is proposed. An accurate temperature control technology combining drilling grouting in non-coal caving area in goaf and buried pipe grouting in coal caving area in goaf is proposed. And the three-dimensional prevention and control system of “wind control-oxygen reduction-temperature suppression” was constructed and applied. The results show that in the past three months of the withdrawal of the working face, the temperature of the goaf is always maintained below 27 ℃, and there is no natural fire sign. The technical system can effectively guarantee the long-term withdrawal safety of the working face.