Abstract: In order to determine the reasonable control countermeasures when a deep-buried roadway encounters a fault with high-water pressure, a transport roadway in Xingdong Coal Mine was taken as an example, and the strength drop and permeability mutation of rocks after failure were considered. The numerical simulation results of the displacement, plastic zone, and permeability coefficient and water inflow of the roadway surrounding rocks were carried out. A combined support control measure of “advance pre-grouting + anchor mesh beam + anchor cable + I-steel shed + shotcrete” was proposed. The research results show that when the advancing face of deep-buried roadway is less than 21 m from the high-pressure fault, as the roadway advances, the displacement, plastic zone and water inflow of the roadway surrounding rocks without support will be exponentially increase. The roof and left side of the deep-buried roadway is the place where the surrounding rock loses stability and water inrush occurs at first. After adopting “advance pre-grouting + anchor mesh beam + anchor cable + I-steel shed + shotcrete” combined support, the convergent displacement, plastic zone depth and water inflow of the roadway near the high-pressure fault will be controlled within 110 mm, 3.2 m and 16 m3/h respectively, which can effectively reduce the probability of water inrush disaster.