Abstract: In order to further improve the efficiency of mine dust reduction, this paper focuses on a new ultrasonic atomization dust reduction method based on the heterogeneous condensation mechanism. The DPM and Mixture dual models are used to numerically simulate the motion flow field and dust diffusion in the ultrasonic atomization dust reduction device. The optimal solution of the parameters of the new ultrasonic atomization dust reduction device was obtained, and combined with the simulation results and the heterogeneous condensation mechanism, we developed an ultrasonic atomization dust reduction experiment platform and carried out the dust reduction experiment. The vertical distance and diameter of the dust suction port of the new ultrasonic atomization dust suppression device are the main factors that affect the air flow movement area and mode inside the device. In this experiment, the vertical distance of the dust suction port is 1.1 m, and the dust particles can fully communicate with each other when the diameter is 0.2 m. For water mist contact, the time of ultrasonic atomization to reduce dust is more suitable. The results show that the new ultrasonic atomization dust reduction method has good atomization and dust reduction performance, and the purification effect of respirable dust is particularly significant, and the dust reduction efficiency reaches 93.54%.