Abstract: Affected by the geological concealment and complexity, there is a potential safety risk of mining induced damage due to insufficient grouting in fissures. Based on the analysis method of combining numerical simulation and microseismic monitoring, the grouting treatment effect of water conducting channel is analyzed based on the background of the grouting floor of 1612A working face in Zhangji Coal Mine. The influence of mining stress and the stability of grouting rock mass are revealed before and after grouting. The results show that: compared with the non-grouting, the abnormal stress area of surrounding rock decreases. The coupling is no longer connected to the working face. After 10 m away from the roadway side, the disturbance degree decreases with the increase of distance. Microseismic monitoring further verified the calculation results: the rock fracture signal “detours” in the grouting affected area. The number of microseismic events in surrounding rock area is small, and the grouted rock mass is in stable state.