Abstract: In order to reduce the interactive influence and harm of the panic emotion of the trapped people in major accidents in coal mines, to enhance the ability of the trapped people to deal with accidents and to promote the effective development of emergency rescue, this paper analyzes the interactive influence and harm of the panic emotion of the trapped in coal mine accident, and puts forward the corresponding coping strategies. The results show that after a major accident in a coal mine, the panic emotion of the trapped people will have an interactive effect among individuals and between individuals and groups, as a result, some individuals and groups’ ability to deal with accidents and their desire to survive are reduced, which greatly affects the effectiveness of accident rescue. Coal mine enterprises should pay attention to the mental health of their employees, strengthen the safety training of business ability and psychological quality, and improve their ability to deal with accidents.