Abstract: Taking Zhushantang Coal Mine as the research background, based on the thermal cycle theory, the original ventilation system of mine central pump room was reformed. The auxiliary shaft was used as the inlet air shaft of the central pump room, the fresh air shaft was used as the return air shaft, and the multi-stage spray room system was set at the wellhead of the auxiliary shaft to construct the thermal cycle system, and the feasibility of the system stability was demonstrated. Finally, the influence of wellbore friction coefficient and wellbore average thermodynamic temperature on the stability of thermal cycle system is analyzed. The results show that: the total ventilation resistance of the thermal cycle system is 131.03 Pa, the ventilation power is 168.63 Pa, the system is stable and reliable; after completion of the thermal cycle system, the air volume load of the mine fan will be released directly by 56.67 m3/s. The total ventilation resistance is positively correlated with the friction resistance coefficient of auxiliary shaft and fresh air shaft. Reducing the friction resistance coefficient of shaft can effectively reduce the total ventilation resistance. The ventilation power is negatively correlated with the average thermodynamic temperature of auxiliary shaft. The lower the average thermodynamic temperature of the auxiliary shaft is, the higher the average thermodynamic temperature of the fresh air shaft is, which is more conducive to the stable operation of the thermal cycle system.