Abstract: In order to scientifically evaluate the comprehensive dust prevention and control capability of coal mine enterprises, process method is used to analyze all dust production activities. Starting from the full chain of coal dust production-reduction-prevention-protection, a comprehensive evaluation model of coal mine dust prevention and control effects based on process method is established to find out the influencing factors of comprehensive prevention and control of coal dust. Based on this, the analysis is carried out from the five levels of dust control technology, dust management, external supervision, personnel protection, and prevention and control effects. A comprehensive assessment system for coal mine dust prevention and control is constructed, and the entropy weight method and set pair analysis method are combined for practical application. The results shows that the dust-proofing technology weight is the largest among the first-level indicators, while the personnel protection weight is the smallest; according to the calculation results of the main value of the contact number, the ranking of the first-grade indicators is in order of external supervision, dust management, personnel protection, prevention effect, prevention dust technology; the main value of the comprehensive contact number of the applied mine is in the “good” evaluation level, and the overall development trend of the mine dust comprehensive prevention and control work is good, but to achieve “better”.