Abstract: In order to study the stability of slope with fault under the action of seepage, the end slope of the third mining area in Yimin Open-pit Mine was taken as the research object, and the similar material model was established and combined with numerical simulation, the stability of slope with fault under the action of seepage is simulated. The results show that the relative position of faults in the slope has a significant influence on the stability of the slope. When the fault is located in the middle of the slope, the deformation and shear stress of the slope are larger, and the fault has the greatest influence on the slope stability. With the advance of the slope, the deformation and stress near the fault decrease, and the influence of the fault on the slope decreases. The main influencing factors of slope stability in different stages of excavation are different. The main factor affecting the slope stability in the early stage of excavation is the fault, which gradually changes into seepage in the later stage. After the fifth excavation, the slope slipped along the weak surface under the coupling action of fault and seepage.