Abstract: In view of problems of co-channel interference emerged in wireless communication in coal mine emergency rescue based on Bluetooth transmission, the paper proposes a method of realizing anti-interference using frequency hopping technology. Mine-used vital sign parameter sensors connect with mine-used data acquisition terminals via Bluetooth signals. When the state of the channel is occupied, a vital sign parameter sensor changes the channels through the way of frequency hopping technology controlled by a data acquisition terminal, which searches in progressive increase for unoccupied channels in order according to the table of Bluetooth channel states and transforms the state of these changed channels into the occupied state. The underground test results indicate that this method can distribute terminals to different channels effectively and avoid the situation of co-channel interference at the same time, which enhances the stability of underground emergency communication system and the capability of emergency rescue.