Abstract: This paper designs a kind of power integrated regional fire-fighting Internet of Things optical port substation, introduces the system architecture, discusses the analog signal isolation anti-interference, switching value and communication isolation circuit, power integrated power supply strategy, network optical port and other key technologies. Take STM32F429 as the control core, combined with the output circuit and control strategy of the sensor, the substation realizes the regional fire-fighting function of full isolation, patrol detection and early warning of the object connection, and integration of power supply and photoelectric port, which improves the anti-interference ability of the monitoring system.