Abstract: To effectively solve the problems of low efficiency of dust suppressant to fine dust and corrosion of spray to equipment and facilities, based on the working mechanism of the chemical dust suppressant, taking the surface tension, contact angle, sedimentation time and settling time as the indicators, the monomer experiments were designed from the aspects of water retention and wettability, and the four chemical dustproof monomers(non-ionic PAM, SA, JFC and DTAB) were selected from the 14 dustproof agents. On the basis of orthogonal test, the best dust inhibitor formulation is optimized as polyacrylamide(non-ionic PAM), sodium alginate, fatty alcohol polyoxyethylene ether, lauryl trimethylammonium bromide and bovine tallow amine, and the mass fraction is 0.20%, 0.15%, 0.20%, 0.09% and 0.01%, respectively. The practical test results show that the formula has good dust-reducing effect, high safety and low corrosivity. The dust removal rate is about 90.0%, the PM10 dust removal rate is about 83.1%, and the respiratory dust removal rate is about 82.4%. The PM2.5 dust removal rate is about 77.3%, and the PM1 dust removal rate is about 53.5%.