Abstract: In order to study the dynamic evolution process of negative pressure influence of the crosscut on the oxygen concentration field in the goaf, the CFD model was developed with the data collected from the fully mechanized mining face of coal mine. The model was used to simulate the distribution of oxygen concentration field when the gas drainage crosscut is located at three different positions of the coal spontaneous combustion three zones in the goaf. The results show that when the gas drainage crosscut is located at different positions of the “three zones” of coal spontaneous combustion, the negative pressure of the crosscut has different effects on the distribution of the oxygen concentration field. When crosscut is located in heat dissipation zone and spontaneous combustion zone, the negative pressure of crosscut can reduce the range of spontaneous combustion zone to different extents, which can effectively alleviate the spontaneous combustion of coal. When the crosscut is located in the suffocating zone, it can reduce the range of the spontaneous combustion zone on the side of return air tunnel, but the range on one side of transportation roadway is expanding rapidly, which is not conducive to fire prevention work in goaf.Finally, the data measured by the on-site beam tube monitoring system are compared with the simulation result, which proves the correctness of the simulation results.