Abstract: To solve the problem of coal spontaneous combustion prevention in 22^# coal seam in Bulianta Mine, the low temperature oxidation analysis of coal samples with different water contents was carried out by using a temperature-programming device to study the oxygen consumption rate, CO and CO₂ production rates and exothermic intensity of coal samples. In addition, the relationship between the absolute amount of CO₂ and the temperature is derived to fit the critical temperature and apparent activation energy. The results show that: the oxygen consumption rate, CO and CO₂ production rates and exothermic strength of coal samples increase first and then decrease with the increase of water content, the moisture content of oxygen consumption rate from high to low is 21.55%>29.50%>13.45%>37.56%>5.53%, CO and CO₂ production rates and exothermic intensity are 21.55%>13.45%>29.50%>37.56%>5.53%; the critical temperature decreases first and then increases with increasing water content, the moisture content of critical temperature from high to low is 37.56%>29.50%>5.53%>13.45%>21.55%; the effect of water on the apparent activation energy is obvious after the critical temperature point, and it decreases first and then increases with the increase of water content, the apparent activation energy of coal sample with water content of 21.55% has the lowest moisture content.