Abstract: To study the influence of interphase force on water-gas two-phase flow in microporous channels, a mathematical model of water-gas two-phase seepage in channel of pore-scale is established by lattice Boltzmann method. The process of water-gas two-phase seepage displacement in microporous channels is simulated by C++ program. it is found that overall displacement effect of two-phase flow is closely related to interphase force. The larger the fluid-solid force, the stronger the hydrophilicity of the porous skeleton, the better the overall displacement effect of the two-phase flow, and vice versa.