Abstract: Based on FLUENT software, based on the site condition of 33 lower 03 working face of Cuizhuang Coal Mine, the coal mine comprehensive excavation roadway model is established. The distribution of air flow and fog droplets in fully mechanized excavation face is simulated by numerical analysis, and the migration laws of fog droplets with air flow is analyzed. The simulation results show that the air flow near the wind tube and the fully mechanized driving machine in the tunnel space is larger, and the maximum wind speed is over 3.2 m/s. The droplet particles move under the action of the roadway air flow and continue to settle. The concentration of fog droplets decreases first, then increases and then decreases and tends to be stable along the path from the head of fully mechanized driving machine to the air outlet.