Abstract: In order to realize the combination optimization of coal mining face gas concentration control measures, based on the system dynamics, the causal relationship structure of gas concentration change and the structure of gas concentration control system were established. The system dynamic behavior of coal seam gas concentration was analyzed, the change law of the gas concentration in the coal mining face with the adjustment of production activity was clarified, and a scientific prediction method of gas concentration and an optimization method of comprehensive control measures were proposed. Results showed that, the factors that affected the change of gas concentration in coal mining face mainly were: yield, ventilation and gas extraction, and the order of influence was yield, gas extraction, ventilation; the dynamic behavior of the gas concentration was exponential oscillatory mode; the combinatorial optimization of the comprehensive control measures of gas concentration could be realized by the nonlinear programming method. Applying the research results to the working face of coal mine, by the combination optimization strategy of reducing the yield per unit area of 87 t/d, increasing the gas extraction capacity of 8 m3/min, and increasing the air volume of return air lane of 93 m3/min, the gas concentration in the working face was reduced from range 0.44% to 0.76% to range 0.22% to 0.51%, which effectively prevented gas accidents.