Abstract: This paper takes the low permeability and difficult coal seam in Guizhou Province as the research object. Methane desorption experiments were carried out at different temperature and moisture content with the HCA high-pressure capacity gas adsorption device. Research showed that the relationship between temperature and gas desorption amount in coal is positive, and the water content is negatively correlated with gas desorption amount in it, the temperature and water content have the most significant influence on gas desorption in coal during the first 30 minutes. Then the quantitative relationship between gas desorption amount in coal under water-heat coupling was deduced with the modified Barrell. Finally, the influence of four different coupling zones on gas desorption capacity in coal is theoretically analyzed.