Abstract: Datai Coal Mine adopts a multi-level intensive mining method, and the mine ventilation system is more complicated. In order to grasp the current situation of the ventilation system of Datai Coal Mine and ensure the safe operation of the mine ventilation system, the resistance measurement of the on-site ventilation system of Datai Coal Mine was carried out by using the pneumatic base point measurement method. The analysis results of the measurement results reveal the operation status of the mine ventilation system. Based on the existing technical means and the actual situation on the site, the rationalization suggestions for the mine ventilation system of Datai Coal Mine are proposed. Through a series of measures, Datai Coal Mine realizes the economical and reasonable operation of the ventilation system.