Abstract: Aiming at the characteristics of heavy workload,multi heading faces,complex construction link,many underground needed wind places in large and middle infrastrcture mine.By the contrast experiment,ventilation system construction of infrastructure mine is determined by temporary mechanical ventilation.Considering all kinds of factors synthetically,during different construction phase of the mine,the relationship between production and equipment should be balanced.The model number of temporary main fan is selected,and two fans are installed near the auxiliary shaft,two air doors are arranged in auxiliary shaft.At last,the mechanical ventilation system is constructed through using main shaft,air shaft to intake air and auxiliary shaft to return air.Practical application shows that the ventilation system is stable,safe,reliable,and easy management,and shortens the construction of the mine project cycle,improves the mine’s ability of countering disaster and reducing disaster,which provides a reference for ventilation system construction of other large and middle construction mines with certain application value.