Abstract: In order to effectively prevent and control coal mine water inrush, according to the characteristics of water inrush diasters under the hydrogeological conditions of Huainan Mining Area, the paper adopts the method of theoretical analysis and engineering practice, especially takes the specific coal seam water inrush example as the research object to make targeted specific statistical analysis and ensure that the results conform to the mine actual situation of the mining area. Through the research and analysis of water source, channels and supply source of water inrush accidents of 12123 bottom suction roadway of Pan’er Mine of Huainan Mining Group, the paper summarizes the advantages and disadvantages of detection methods and management measures mine for water inrush, and concludes the better detection methods and control measures for preventing and controlling regional limestone water of Huainan Coal Mine by drawing on the water treatment technology system of Huaibei Mining Area.