Abstract: Due to the great changes of underground stope in Yujialiang Mine, the effective air volume at the operation site is much richer, and the mine ventilation system is more complex. In view of the present situation of this ventilation system, combining with the mining and connecting arrangement and the demands for wind in the next five years, the adjustment scheme of the mine ventilation system is demonstrated and analyzed. The optimal system adjustment scheme is obtained. The main ventilator of 42^# coal is suspended in accordance with the final decision of the scheme, and the ventilation system of the whole mine is adjusted to meet the requirements of mine safety production and air demand, and ventilation system is stable and reasonable and achieves good results.