Abstract: The TOPSIS safety evaluation model of coal mine based on the combination of game theory is established for the objective evaluation of coal mine safety. Firstly, the theory of game theory is used to optimize the weights of fuzzy analytic hierarchy process （FAHP） and entropy weight method. Secondly, the comprehensive evaluation model of coal mine safety status is constructed by combining the combination weights with closeness degree matrix of the samples calculated by the TOPSIS method. Finally, the model is used to evaluate the safety status of five coal mines in Yima Coal Industry in Henan Province. Meanwhile, the evaluation results of this model are compared with those of FAHP-TOPSIS model and entropy weight-TOPSIS model. The results show that the evaluation results of the model are basically consistent with the actual safety situation of the coal mine, and the evaluation result of the model is more scientific and accurate.