Abstract: The uranium is upon the coal in vertical profile between the east wing of Tarangaole Mine and Nalinggou Uranium Mine, for the sake of avoiding the groundwater level reduced in the uranium deposit area due to coal mining, it is necessary to design the optimal mining scheme to build the hydraulic curtain between the coal and uranium. The three-dimensional numerical model of unsteady flow of groundwater is established by the finite difference method, which is used to simulate the groundwater level dynamic state under the different mining schemes. By comparing the fluctuation and influence range of underground water level in coal mine area and uranium mine area under different mining schemes, the optimal mining plan is optimized. The mining plan Ⅱ has the least influence on the groundwater in uranium mining area, which can be used as the optimal mining scheme for the coordinated exploitation of underground hydraulic curtain.