Abstract: In the project of grouting and blocking water, using different mathematical calculation models of permeability and test parameters can lead to different evaluation results during the utilization of water pressure test on quantitatively evaluation on single borehole grouting effect. On the basis of the system analysis and summarizing the mathematical model of permeability and its applicable conditions, the difference of permeability coefficients of rock mass, which are calculated by equations, is quantitatively analyzed. Additionally, this paper proposes that conventional mathematical calculation model of permeability coefficient, which applies to water pressure test in tube-well borehole, is inapplicability in nearly horizontal and branch directional bedding borehole of radial well. In accordance with the analysis on impact of different test parameters on single borehole grouting effect, and from the point of mine water hazard prevention and control technology and the technology of grouting and blocking water, the paper gives the parameter selection standard, assessing methods, and steps of evaluation.