Abstract: Through the optimization practice of four mine ventilation systems, the paper discusses the current situation of the existing aging mine ventilation system, combined with the actual situation of old mines, on the basis of the mine ventilation resistance measurement, using MVS simulation software, the paper analyzes ventilation line optimization scheme of the 307 panel and 408 panel and the feasibility of the independent operation of the main fan in Luojiaxinyao village and the outage of main fan in Ertai village, and verifies the optimized ventilation system. The verification results show that the optimized scheme is safe and feasible.