Abstract: For the problems of high negative pressure and low flow rate in Changcun Coal Mine gas drainage system, a new calculation method for pipe flow resistance of compressible fluid theory was proposed. Based on this method and take the gas drainage system as a tree map network, a mine gas drainage network solution system was developed. The developed network solution system is utilized to optimize the gas extraction pipelines in mines and serious problems are found in the resistance loss of the drainage pipelines. By optimizing the pipe network, suction negative pressure, pipe diameters of gas drainage system, the negative pressure loss of the drainage system was reduced, and the extraction rate was increased. At the same time, five optimization schemes were given for the connection method of the gas extraction pump system and gas pump in Changcun Coal Mine. Meanwhile, the simulated results and comparison were carried out respectively. The results showed that pure quantity of the drainage gas of the total mine was increased by 0.001 5 m³/s, with an increase rate of 0.169 7% in the scheme two. The fourth plan is to stop the low-negative-pressure pumping station on the ground. After stopping the pump, the total extraction volume of the mine was decreased by 1.312 6 m³/s, and the gas extraction volume was decreased by 0.052 0 m³/s.