Abstract: In order to solve the problems that the safety protection of mine automatic production system is weak and the industrial control system protocol can not be effectively protected by traditional safety protection equipment, according to the the requirements of the national Guidelines for Information Safety Protection of Industrial Control System, this paper studies the comprehensive safety protection measures through the boundary protection of the mine industrial control network, the real-time monitoring of the ground control center and the safety reinforcement of the host computer. The practical application was carried out in Pingdingshan Coal Group No.8 Mine. The results show that the comprehensive utilization of the above measures effectively improve the safety level of the mine production automation system, reduce the system interruption caused by virus or Trojan attack in mine production control system and ensure the safe and reliable operation of mine automatic production system.