Abstract: Full tailing cemented backfills were produced by one ore tailing with the ratio of 1∶4, 1∶6, 1∶8 and 1∶10, the slurry concentration of 65%, 70% and 72%. The uniaxial compressive strength test was carried out after 3, 7 and 28 days of curing to explore the relationship between the backfills’ strength and various factors. The results show that the backfills’ strength following polynomial function increases with the increase of the lime-to-sand ratio, following exponential function increases with the increase of slurry concentration, and following exponential function increases with the increase of the curing period. The higher the lime-to-sand ratio, the lower the slurry concentration, and the greater the effect of curing period on the backfills’ strength, which indicates that, the effect of multi-factor coupling on the backfills’ strength is more significant. Excel and SPSS were used together to present the regression equation of backfills’ strength and the slurry concentration, lime-to-sand ratio. The correlation coefficient of the regression equation is high, the significance is strong, and it can better characterize the influence of each factor on the backfills’ strength.