Abstract: At present, China’s economy is changing from high speed development to high quality development, and the safety engineering is complex and changeable, so it is particularly urgent to train the safety engineering innovative talents. Through the analysis of the safety engineering talents characteristics, we discuss the cultivation mode of the safety engineering innovative talents. Taking the engineering example as the main training mode, the innovative talents of safety engineering are cultivated. We carried out the engineering example class of “mine ventilation and safety” to make the student to be an application-oriented senior specialized personnel with innovative spirit and practical ability through the basic knowledge of mine ventilation and related engineering cases to cultivate and stimulate students’ creative ability.