Abstract: The simulation and prediction of mine inflow are carried out with the mining process in real time because the coal mining is a dynamic process. Taking Hulusu Coal Mine as an example, Visual Modflow was used to establish the numerical modeling of groundwater flow, and then we predict the dynamic change of water yield of mine with the mining progress and calculate the water yield of mine during 10 years of excavation. The results show that the water yield of mine is small in the first mining area and the water yield of mine increases gradually with the increase of the mining face. In the process of mining in the first mining area, the water inflow of the mine increases with the increasing of the mining space, and finally tends to be stable.