Abstract: Due to the complexity of geological conditions and the lack of experimental materials, the influence factors are random, fuzzy, grey, unknown, and so on. To solve these problems, new method is introduced based on qualitative uncertainty measurement cloud model and the synthesis rules of conflict evidence of D-S theory, and using cloud model combined fuzziness and randomness of water inrush evaluation, the evaluation index realizes uncertainty transform from qualitative to quantitative; using conflicting evidence synthetic method of D-S theory, the conflict between the fused data is eliminated to determine the more reasonable weights of evaluation indexes; comprehensively considering the factors of water, drainage factors, human factors and management factors, the system of water inrush risk comprehensive evaluation of coal mine is constructed to evaluate Nanshan Coal Mine water inrush risk. The evaluation result is a “safer” grade, which conforms to the engineering practice. The engineering example shows that the comprehensive evaluation of coal mine water inrush risk based on cloud model and D-S theory is accurate, reliable and accurate, and has high application value.