Abstract: Find out the best multi-component acid formula for enhancing the permeability of different coal rank can provide a certain theoretical basis for the application of multi-component acid in coal reservoir acidizing. In this paper, collect different rank samples （Henan Yima Qianqiu Coal Mine, Shanxi Changping Coal Mine and Shanxi Tunlan Coal Mine）, we carry out the dissolution experiments of multi-component acid on different coal rank, according to dissolution characteristics of different multi-component acid on different coal samples, we selected the optimal formula of different coal rank acid. By coal permeability experiment before and after the acidification test, we obtained that the coal permeability of coal samples in Qianqiu Coal Mine, Tunlan Coal Mine, Changping Coal Mine increased by 25.76 to 128.08 times, 0.32 to 1.20 times and 0.73 to 17.22 times after acidification, which has good acid antireflective effect.