Abstract: To promote the safety of mine production and provide scientific basis for the design of airtight wall, taking the anti-impact airtight wall in Shenhua Group as the object, we establish the calculation model of airtight wall through ANSYS Workbench software, set four different loading curves to impact the wall, and use transient analysis to obtain the stress state of the wall under four kinds of different sustained explosion load. By analyzing the force distribution of the wall, we obtain the safety under the impact of a certain strength. The numerical simulation results show that the safety performance of the airtight wall is good under a given load. The dangerous areas of the airtight wall that is easy to be damaged are mainly at the back of the innerwall and the cuttings, and rebar can be added to the inner wall to reduce damage.