Abstract: Virtualization is an important and advanced, breakthrough technology, coal mine has been widely used virtualization technology in the fields of servers, data center to efficiently use computing resources to reduce the cost of purchasing software and hardware equipment and realize the safe operation of the network. In response to the safety risks of network virus, the improvement for data safety and infrastructure safety strategies are carried out. Through virtualization deployment and overall scheduling and other measures, the spread and attack of “eternal blue” blackmail virus is effectively defended against, and the normal operation and safe production of core application system of China Pingmei Shenma Group is guaranteed.