Abstract: In order to effectively solve blasting and slope stability of open-pit mining under high temperature fire occurrence mode, we propose comprehensive fire prevention and extinguishing scheme according to the characteristics of fire distribution. The scheme includes surface covering, drilling and grouting, stripping for fire extinguishing. We take “wide pitch-row, double row pitch” loose deep hole millisecond blasting under “three stages” temperature monitoring mode, PVC tube interval charging process to improve the blasting effect. According to the theory of explosive stress wave, explosive gas quasi-static theory, we determinate the fracture radius of the drilling, critical resistance value, borehole spacing, minimum charging depth. Using Hawk abas method, we determine slope angle, stability factor. Aiming at the slope deformation and sliding, taking the anti-sliding measures, like anchor cable, hanging nets to increase the friction of sliding surface, the stability of slope will be guaranteed effectively.