Abstract: In order to determine the reasonable ventilation mode and air volume of coal and gas compound disaster face in Nashan Mine, taking 33183 face as the research object, Fluent software is used to analyze the gas and oxygen concentration distribution and temperature field distribution. The results show that“U + L” and“Y” ventilation can solve the gas problem, but have difficulties to solve the fire from the width of oxidation zone and the characteristics of high temperature zone; the “U” ventilation method is beneficial to the fire prevention with the gas extraction technology to solve the gas overrun problem. The reasonable ventilation of 33183 face is“U” ventilation, which can meet the requirement of gas drainage and controling the spontaneous combustion of coal.