Abstract: This paper analyzes the influence of "one ventilation and three prevention" major disasters in Shendong Mining Area on mine safety production, formulates the corresponding control measures and takes the "one ventilation and three prevention" work as a top priority. Insisting problem orientation and goal orientation, earnestly implementing the prevention and control planning of major disasters in coal mines, accomplishing advance prevention, strengthening scientific research, further improving the disaster prevention and control capacity of coal mines, all of these ensure the high production and efficiency safety production of mines.