Abstract: Taking No.5 panel of Bulianta Coal Mine as the research object, three-dimensional seismic exploration technology is used to predict the thickness of main coal seam in mining area to clear the occurrence condition of coal seam and provide reference data for the safety and efficient development of the subsequent mining operation. Results show that three-dimensional seismic exploration technology realizes effective prediction of thickness variation of main mineable coal seam, and compiles corresponding thickness variation trend chart for the data accumulation of follow-up production work. But, due to the limitations of the survey data, the prediction of coal seam thickness is only qualitative and semi quantitative interpretation and the results just can be as a reference.