Abstract: In order to study the influence of lithological characters and location on tunnel surrounding rock asymmetric deformation during deep mining, the displacement change characteristics, stress distribution and plastic deformation of deep inclined roadway under the relationship of different lithological characters and locations are simulated by FLAC^3D. Research showed that the relations of lithological characters and location had great influece on roadway surrounding rock asymmetric deformation when roadway placed in hard rock; when roadway placed in softer rock, the effect was less obviously; when roadway placed in harder rock, location relation affected gently; lithological character played a key role in surrounding rock deformation and the surrounding rock stress distribution, and the harder the lithological character of surrounding rock, the more serious of stress concentration, the bigger of maximum lateral stress and maximum vertical stress difference value. The change of location relationship had less effect on plastic deformation scale of surrounding rock, but had great effect on plastic damage pattern of surrounding rock.