Abstract: Based on the geological conditions at 3^# coal seam in a mine whose work face belongs to "three-intake two-return" ventilation type, a mining adopted roadway layout of stagger arrangement was applied to optimize the roadway layout in this coal mine. Through the comparison of coal loss ratio, easy degree of gas emission and roadway driving and maintenance of roadway in new and old approaches, the unique advantage of stagger arrangement of roadway used in "three-intake two-return" ventilation type work face had been gained preliminarily. Then, the regional stress-displacement distribution around the reuse roadway of two roadway layouts was studied by using FLAC^3D numerical simulation after work face extraction. The simulating results showed that the roadway layout of stagger arrangement could not only greatly reduce the loss of coal mining, but also could greatly decrease the area of lateral stress concentration of coal pillar and minish the amount of movement of roadway roof and floor. Therefore, this roadway layout method is much beneficial to the roadway's driving and maintenance.