Abstract: Because of unique frozen soil environment of the Qinghai-Tibet Plateau,it determines that the particularity and complexity of factors which influence the slope stability of open-pit mining.According to the geological perambulation report of the coal field and combining with engineering geology survey of the open-pit mine and characteristics of slope failure,the influencing factors of the slope stability of open-pit mine are analyzed.The results show that in addition to stratigraphic lithology,geological structure,groundwater effect and human factors are main factors of influencing open-pit mine slope stability,the effect of frozen soil also plays an important role.On the basis of the above views,the prevention and control measures for slope instability are put forward.